Helicobacter
Helicobacter Treatment Diets for Rodents
We manufacture special diets for the oral dosing of combinations of compounds for eradication of Helicobacter spp. The traditional approach is a three-drug combination; a new approach combines four drugs. All these formulas are based on LabDiet® 5001 grain-based rodent diet. Custom tablets based on other LabDiet® products may also be formulated on request.
Dosage and duration of treatment should be determined by veterinary professionals.
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The traditional approach... |
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Three-Drug Combo |
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Commonly used to treat early or acute infections, weanlings, or juveniles, usually in mice, but sometimes used in rats. Also used to treat dams for offspring free of Helicobacter. Tablets can be fed ad lib, or one 5-gram tablet per day per average mouse (20 gm) to satisfy both the daily nutritional and medication needs (larger rates, certain strains, males may need additional food). Successful eradication requires a comprehensive husbandry plan in addition to medication. (See the articles cited below and consult your veterinary professionals.)
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Available as: |
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- A 5-gram tablet with |
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3.000 mg Amoxicillin (0.06%) |
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0.690 mg Metronidazole (0.0138%) |
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0.185 mg Bismuth (0.0037%) |
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Specifications: TestDiet® Formula #5TXV |
Irradiated 5-gram tablet = Product Code: 1811316 Non-Irradiated 5-gram tablet = Product Code: 1811235 |
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- An ad lib diet based on LabDiet® 5001, containing |
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0.0600% Amoxicillin |
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0.0138% Metronidazole |
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0.0037% Bismuth with bacon flavor |
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Specifications: TestDiet® Formula #588V |
Irradiated 1/2" pellet = Product Code: 46628 Non-Irradiated 1/2" pellet = Product Code:46595 |
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A newer approach... |
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Four-Drug Combo ***See the most recent article cited below. |
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A treatment most effective against a broader range of Helicobacter strains, and against chronic or well-established infections in adult or breeder rodents. Also used to treat dams for offspring free of Helicobacter. Tablets can be fed ad lib, or one 5-gram tablet per day per average mouse (20 gm) or three to four 5-gm tablets per day per average rat (250 gm) to satisfy both the daily nutritional and medication needs (larger rates, certain strains, males may need additional food). Successful eradication requires a comprehensive husbandry plan in addition to medication. (See the articles cited below and consult your veterinary professionals.)
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Available as: |
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- A 5-gram tablet for MICE with |
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3.00 mg Amoxicillin (0.06%) |
Average dose for mice: |
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0.50 mg Clarithromycin (0.01%) |
One 5-gm tablet per 20 gm of body weight |
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1.00 mg Metronidazole (0.02%) |
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0.02 mg Omeprazole (0.0004%) |
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Specifications: TestDiet® Formula #5TXW |
Irradiated 5-gram tablet = Product Code: 1811317 Non-Irradiated 5-gram tablet = Product Code: 1811236 |
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- A 5-gram tablet for RATS with |
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10.0 mg Amoxicillin (0.2%) |
Average dose for rats: |
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1.70 mg Clarithromycin (0.034%) |
One 5-gm tablet per 75 gm of body weight |
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3.30 mg Metronidazole (0.066%) |
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0.07 mg Omeprazole (0.0014%) |
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Specifications: TestDiet® Formula #5TXX |
Irradiated 5-gram tablet = Product Code: 1811318 Non-Irradiated 5-gram tablet = Product Code: 1811237 |
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Selected References:
***The most recent publication on the Four-Drug Combo:
Kostomitsopoulos, N, et al. 2007 (May) Eradication of Helicobacter bilis and H. hepaticus from infected mice by using a medicated diet. Lab Animal 36(5):37-40.
Abstract: Infection of laboratory mice with Helicobacter spp. is a serious problem…. Rederivation and antibiotic treatment are two of the most common methods used to eliminate the bacterial infection…. Forty-seven newly imported mice were suspected to be positive for Helicobacter infection based on positive PCR analysis…. We treatedwith a medicated feed containing four antibiotics (amoxicillin, clarithromycin, metronidazole, omeprazole). After eight weeks of continuous administration the animals were negative for H. bilis and H hepaticus. Frequent retesting of the animals for up to one year proved that the mouse colony remained negative for Helicobacter spp.
Conclusion: Based on our experiences, the [four-drug] combination … is effective in the eradication of [Helicobacter] in immunocompetent mice. Considering the cost of treatment and the risk of reoccurrence of the infection, the use of antibiotics is an acceptable alternative to line rederivation.
Jury, J. et al. 2005 (July). Eradication of Helicobacter spp From a Rat Breeding Colony. Contemporary Topics in Lab. An. Sci. 44(4):8-11
Whary, M. & Fox, J. 2004 (April). Natural and Experimental Helicobacter Infections. Comp. Med. 54(2) 128-158.
Whary, M. et al. 2000 (Feb). Containment of Helicobacter hepaticus by Use of Husbandry Practices. Comp. Med. 50(1):78-81.
See also:
Precise Dosage Medicated Tablets
