References – Obesity

 

A representative listing of journal articles and other published research reporting how diet formulas have been used in research.

 

Ahrιn B, et al. Plasma leptin and insulin in C57Bl/6J mice on a high-fat diet: relation to subsequent changes in body weight. Acta Physiol. Scand. 1999;165:233-40.

Bachman ES, Dhillon H, Zhang C, Cinti S, Bianco AC, Kobilka BK & Lowell BB.ίAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance. Science. 297:843-845. 2002

Bagnasco, M., M. G. Dube, A. Katz, P. S. Kalra, and S. P. Kalra. Leptin Expression In Hypothalamic Pvn Reverses Dietary Obesity And Hyperinsulinemia But Stimulates Ghrelin. Obes Res. 11:1463–1470, 2003.

Bartness, R. J., Bittman, E. L., Wade, G. N. (1985) Paraventricular nucleus lesions exaggerate dietary obesity but block photoperiod-induced weight gains and suspension of estrous cyclicity in syrian hamsters. Brain Res Bull 14(5): 427-430.

Bartness, T. J., Bittman, E. L., Wade, G. N. (1985) Paraventricular nucleus lesions exaggerate dietary obesity but block photoperiod-induced weight gains and suspension of estrous cyclicity in syrian hamsters. Brain Res Bull 14(5): 427-430.

Bizeau ME, Short C, Thresher JS, Commerford SR, Willis WT, & Pagliossotti MJ. Increased pyruvate flux capacities account for diet-induced increases in gluconeogenesis in vitro. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281:R427-R433, 2001.

Bluher, S., Responsiveness to Peripherally Administered Melanocortins in Lean and Obese Mice. Diabetes 53:82–90, 2004.

Brunengraber, D. Z., et al. Influence of diet on the modeling of adipose tissue triglycerides during growth. Am J Physiol Endocrinol Metab 285: E917–E925, 2003.

Bunag, R. D., Krizsan, D., Itoh, H. (1990) Diminished cardiovascular responsiveness to vagalstimulation in obese rats. American J of Physiology 259(4): R842-848.

Castonguay, T. W., Dallman, M. F., Stern, J. S. (1986) Some metabolic and behavioral effects of adrenalectomy on obese Zucker rats. American J of Physiology 251(4): R923-933.

Commerford SR, Pagliossotti MJ, Melby CL, Wei Y, & Hill JO. Inherent capacity for lipogenesis or dietary fat retention is not increased in obesity-prone rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 280:R1680-R1687, 2001.

Commerford SR, Pagliossotti MJ, Melby CL, Wei Y, Gayles EC, & Hill JO. Fat oxidation, lipolysis, and free fatty acid cycling in obesity-prone and obesity-resistant rats. Am. J. Physiol. Endocrinol. Metab. 279:E875-E885, 2000.

Conarello, S. L., et al. Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance. PNAS, 100:11: 6825–6830, 2003.

Dhar, M. S., et al. Mice Heterozygous for Atp10c, a Putative Amphipath, Represent a Novel Model of Obesity and Type 2 Diabetes. J. Nutr. 134: 799–805, 2004.

Dobrian AD, Davies MJ, Prewitt RL, & Lauterio TJ. Development of hypertension in a rat model of diet-induced obesity. Hypertension. 2000; 35:1009-15.

Dobrian AD, Davies MJ, Schriver SD , Lauterio TJ, & Prewitt RL. Oxidative stress in a rat model of obesity-induced hypertension. Hypertension 2001; 37:554-560.

Dube MG, Beretta E, Dhillon H, Ueno N, Kalra PS & Kalra SP. Central Leptin Gene Therapy Blocks High-Fat Diet-Induced Weight Gain, Hyperleptinemeia, and Hyperinsulinemia. Diabetes 51:1729-1736, 2001.

El-Haschimi K, et al. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J.Clin.Invest. 2000; 105:1827-1832.

Farley, C., J. A. Cook, B. D. Spar, T. M. Austin, and T. J. Kowalski. Meal Pattern Analysis Of Diet-Induced Obesity In Susceptible And Resistant Rats. Obes Res. 11:845–851, 2003.

Felipe, F., M.L. Bonet, J. Ribot and A. Palou. Up-regulation of muscle uncoupling protein 3 gene expression in mice following high fat diet, dietary vitamin A supplementation and acute retinoic acid-treatment. International Journal of Obesity 27: 60–69, 2003.

Fisher H., Halladay A., Ramasubramaniam N., Petrucci J.C., Dagounis D., Sekowski A., Martin J.V., & Wagner G.C. Liver Fat and Plasma Ethanol Are Sharply Lower in Rats Fed Ethanol in Conjunction with High Carbohydrate Compared with High Fat Diets. J. Nutr. 132: 2732-2736. 2002

Fu, J., et al. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR. Nature 425:90-93, 2003.

Gao, J., L. Ghibaudi, M. Van Heek, J. J. Hwa. Characterization of diet-induced obese rats that develop persistent obesity after 6 months of high-fat followed by 1 month of low-fat diet. Brain Research 936:87–90, 2002.

Gavrilova, O., et al. Liver Peroxisome Proliferator-activated Receptor Contributes to Hepatic Steatosis, Triglyceride Clearance, and Regulation of Body Fat Mass. The Journal of Biological Chemistry 278:36:34268–34276, 2003.

Gayles EC, Pagliassotti MJ, Prach PA. Koppenhafer TA, & Hill JO. Contribution of energy intake and tissue enzymatic profile to body weight gain in high-fat-fed rats. Am. J. Physiol. 272:R188-R194, 1997.

Ghibaudi L, Cook J, Farley C, Van Heek M, & Hwa J. Fat Intake Affects Adiposity, Comorbidity Factors, and Energy Metabolism of Sprague-Dawley Rats. Obes. Res. 10:956-963. 2002

Ghibaudi L, Cook J, Farley C, Van Heek M, & Hwa J.Fat Intake Affects Adiposity, Comorbidity Factors, and Energy Metabolism of Sprague-Dawley Rats. Obes. Res. 10:956-963. 2002

Hancock, A.A. et al. Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist. European Journal of Pharmacology 487:183–197, 2004.

Harris RBS, Mitchell TD, & Hebert S (Pennington Biomedical Research Center, Baton Rouge, LA). Leptin-Induced Changes in Body Composition in High Fat-Fed Mice. AJP-Regul Integr Comp Physiol 284:R87-R100, 2003.

Hildebrandt, A. L., D. M. Kelly-Sullivan, S. C. Black. Antiobesity effects of chronic cannabinoid CB1 receptor antagonist treatment in diet-induced obese mice. European Journal of Pharmacology 462:125–132, 2003.

Hildebrandt, A. L., D. M. Kelly-Sullivan, S. C. Black. Validation of a high-resolution X-ray computed tomography system to measure murine adipose tissue depot mass in situ and longitudinally. Journal of Pharmacological and Toxicological Methods 47: 99– 106, 2002.

Hileman, S. M., D.D. Pierroz, H. Masuzaki, C. Bjψrbζk, K. El-Haschimi, W. A. Banks, and J. S. Flier. Characterizaton of Short Isoforms of the Leptin Receptor in Rat Cerebral Microvessels and of Brain Uptake of Leptin in Mouse Models of Obesity. Endocrinology 143:775–783, 2002.

Ho, A., Chin, A. (1988) Circadian feeding and drinking patterns of genetically obese mice fed solid chow diet. Physiol Behav 43(5): 651-656.

Ishii, M., H. Fei, and J. M. Friedman. Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity. PNAS 100:18:10540–10545, 2003.

Joseph, J. W., V. Koshkin, C-Y Zhang, J. Wang, B. B. Lowell, C. B. Chan, and M.B. Wheeler. Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin Secretory Capacity After a High-Fat Diet. Diabetes 51:3211–3219, 2002.

Keenan, K. P. (1998) Effects of diet and overfeeding on body weight and survival in the rodent bioassay: The impact on pharmaceutical safety assessment. International Journal of Toxicology 17: 101-117.

Keenan, K. P., Ballam, G. C., Dixit, R., Soper, K. A., Laroque, P., Mattson, B. A., Adams, S. P., Coleman, J. B. (1997) The effects of diet, overfeeding and moderate dietary restriction on Sprague-Dawley rat survival, discease and toxicology. Journal of Nutrition 127(5): 851S-856S.

Keenan, K. P., Laroque, P., Ballam, G. C., Soper, K. A., Dixit, R., Mattson, B. A., Adams, S. P., Coleman, J. B. (1996) The effects of diet, ad libitum overfeeding, and moderate dietary restriction on the rodent bioassay: the uncontrolled variable in safety assessment. Toxicologic Pathology 24(6): 757-768.

Keenan, K. P., Laroque, P., Coleman, J. B., Cook, W. O., Dixit, R., Soper, B. A., Mattson, K. A., Ballam, G. C. (1996) The subchronic effects of ad libitum overfeeding and moderate or marked dietary restriction (DR) on biomarkers of longevity, degenerative disease, and carcinogenesis in the Sprague-Dawley rat. Toxicologic Pathology 24(6): 788.

Keenan, K. P., Laroque, P., Soper, K. A., Morrissey, R. E., Dixit, R. (1996) The effects of overfeeding and moderate dietary restriction on Sprague-Dawley rat survival, pathology, carcinogenicity, and the toxicity of pharmaceutical agents. Exp Toxicologic Pathology 48(2-3): 139-144.

Keenan, K. P., Smith, P. F., Hertzog, P., Soper, K., Ballam, G. C., Clark, R. L. (1994) The effects of overfeeding and dietary restriction on Sprague-Dawley rat survival and early pathology biomarkers of aging. Toxicologic Pathology 22(3): 300-315.

Keenan, K. P., Soper, K. A., Hertzop, P. R., Gumprecht, L. A., Smith, P. F., Mattson, B. A., Ballam, G. C., Clark, R. L. (1995) Diet, overfeeding, and moderate dietary restriction in control Sprague-Dawley rats: II. Effects on age-related proliferative and degenerative lesions. Toxicologic Pathology 23(3): 287-302.

Keenan, K. P., Soper, K. A., Smith, P. F., Ballam, G. C., Clark, R. L. (1995) Diet, overfeeding, and moderate dietary restriction in control Sprague-Dawley rats: I. Effects on spontaneous neoplasms. Toxicologic Pathology 23(3): 269-286.

Kumar, M. V., T. Shimokawa, T. R. Nagy, and M. D. Lane. Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice. PNAS 99:4: 1921–1925, 2002.

Lambert, P. D., et al. Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity. PNAS 98:8: 4652–4657, 2001.

Laroque, P. A., Hubert, M-F., Keenan, K. P., Duprat, P. (1996) The effects of ad libitum overfeeding and moderate or severe dietary restriction on spontaneous degenerative and proliferative lesions in Sprague-Dawley rats. Toxicologic Pathology 24(6): 787.

Lauterio TJ, Barkan A, DeAngelo M, DeMott-Friberg R, & Ramirez R. Plasma growth hormone secretion is impaired in obesity-prone rats before onset of diet-induced obesity. Am. J. Physiol. 1998; 275:E6-11.

Lauterio TJ, Davies MJ, DeAngelo M, Peyser M, & Lee J. Neuropeptide Y Expression and Endogenous Leptin Concentration in a Dietary Model of Obesity. Obes. Res.. 1999; 7:498-505.

Lauterio TJ, et al. Development and characterization of a purified diet to identify obesity-susceptible and resistant rat populations. J. Nutr. 1994; 124:2172-2178.

Le Laya, S., et al. Decreased Resistin Expression in Mice with Different Sensitivities to a High-Fat Diet. Biochemical and Biophysical Research Communications 289:2:564-567, 2001.

Levin BE, et al. (1987) Glucose-induced norepinephrine levels and obesity resistance. Am J Phys.253(3 Pt 2):R475-81.

Levin BE, et al. Resistance to diet-induced obesity: food intake, pancreatic sympathetic tone, and insulin. Am. J. Phys.252(3 Pt 2):R471-R478, 1987.

Levin, B. E. and A. A. Dunn-Meynell. Defense of body weight against chronic caloric restriction in obesity- prone and -resistant rats. Am.J.Physiol Regul.Integr.Comp Physiol 278: R231-R237, 2000.

Levin, B. E. and A. A. Dunn-Meynell. Defense of body weight depends on dietary composition and palatability in rats with diet-induced obesity. Am.J.Physiol Regul.Integr.Comp Physiol 282: R46-R54, 2002.

Levin, B. E. and A. A. Dunn-Meynell. Dysregulation of arcuate nucleus preproneuropeptide Y mRNA in diet- induced obese rats. Am.J.Physiol 272: R1365-R1370, 1997.

Levin, B. E. and A. A. Dunn-Meynell. Sibutramine alters the central mechanisms regulating the defended body weight in diet-induced obese rats. Am.J.Physiol Regul.Integr.Comp Physiol 279: R2222-R2228, 2000.

Levin, B. E. and E. Govek. Gestational obesity accentuates obesity in obesity-prone progeny. Am.J.Physiol 275: R1374-R1379, 1998.

Levin, B. E. and R. E. Keesey. Defense of differing body weight set points in diet-induced obese and resistant rats. Am.J.Physiol 274: R412-R419, 1998.

Levin, B. E. Arcuate NPY neurons and energy homeostasis in diet-induced obese and resistant rats. Am.J.Physiol 276: R382-R387, 1999.

Levin, B. E. Reduced norepinephrine turnover in organs and brains of obesity-prone rats. Am.J.Physiol 268: R389-R394, 1995.

Levin, B. E., A. A. Dunn-Meynell, B. Balkan, and R. E. Keesey. Selective breeding for diet-induced obesity and resistance in Sprague- Dawley rats. Am.J.Physiol 273: R725-R730, 1997.

Levin, B. E., D. Richard, C. Michel, and R. Servatius. Differential stress responsivity in diet-induced obese and resistant rats. Am.J.Physiol Regul.Integr.Comp Physiol 279: R1357-R1364, 2000.

Levin, B. E., E. K. Govek, and A. A. Dunn-Meynell. Reduced glucose-induced neuronal activation in the hypothalamus of diet- induced obese rats. Brain Res. 808: 317-319, 1998.

Levy JR, Lesko J, Krieg RJ, Adler RA & Stevens W. Leptin responses to glucose infusions in obesity-prone rats. Am J Physiol Endocrinol Metab 2000; 279:E1088-1096.

Ludwig, D. S., et al. Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. J. Clin. Invest. 107:379–386, 2001.

Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, Flier JS. A Transgenic Model of Visceral Obesity and the Metabolic Syndrome. Science. 2001; 294:2166-2170.

Moon, Y. S., et al. Mice Lacking Paternally Expressed Pref-1/Dlk1 Display Growth Retardation and Accelerated Adiposity. Molecular And Cellular Biology 22:15: 5585–5592, 2002.

Morin CL, Eckel RH, Marcel T, & Pagliassotti MJ. High fat diets elevate adipose tissue-derived tumor necrosis factor- alpha activity. Endocrinology 138:4665-4671, 1997.

Morton, J. L., Davenport, M., Beloff-Chain, A., Bodkin, N. L., Hansen, B. C. (1992) Correlation between plasma beta cell tropin concentrations and body weight in obese Rhesus monkeys. American J of Physiology 262(6), Part 1: E963-967.

Murray I, Havel PJ, Sniderman AD & Cianflone K. Reduced Body Weight, Adipose Tissue, and Leptin Levels Despite Increased Energy Intake in Female Mice Lacking Acylation-Stimulating Protein. Endocrinology. 141:1041-1049; 2000

O'Brien, D. W. (1981) The effect of prolonged physical training and high fat diet on heart size and body weight in rats. Can J Physiol Pharmacol 59(3): 268-272.

Oscai, L. B., Brown, M. M., Miller, W. C. (1984) Effect of dietary fat on food intake growth and body composition in rats. Growth 48(4): 415-424.

Oscai, L. B., Miller, W. C. (1986) Dietary-induced severe obesity exercise implications. Med Sci Sports Exercise 18(1): 6-9.

Oscai, L. B., Miller, W. C., Arnall, D. A. (1987) Effects of dietary sugar and of dietary fat on food intake and body fat content in rats. Growth 51(1): 64-73.

Pagliassotti MJ, Horton T J, Gayles EC, Koppenhafer TA, Rosenzweig TD, and. Hill JO. Reduced insulin suppression of glucose appearance is related to susceptibility to dietary obesity in rats. Am.J.Physiol 272: R1264-R1270, 1997.

Pagliassotti MJ, Knobel SM, Shahrokhi KA, & Hill JO. Time course of adaptation to a high-fat diet in obesity-resistant and obesity-prone rats. Am. J. Physiol. 267:R659-R664, 1994

Pagliassotti MJ, Shahrokhi KA, & Hill JO. Skeletal muscle glucose metabolism in obesity-prone abd obesity-resistant rats. Am. J. Physiol. 264:R1224-R1228, 1993. 7.

Pagliassotti, M et al. Tissue oxidative capacity, fuel stores and skeletal muscle fatty acid composition in obesity-prone and obesity-resistant rats. Obes. Res. 3:459-64, 1995.

Parkinson, W. L., Weingarten, H. P. (1990) Dissociative analysis of ventromedial hypothalmic obesity syndrome. American J of Physiology 259(4): R829-835.

Pierroz, D. D., M. Ziotopoulou, L. Ungsunan, S. Moschos, J. S. Flier, and C. S. Mantzoros. Effects of Acute and Chronic Administration of the Melanocortin Agonist MTII in Mice With Diet-Induced Obesity. Diabetes 51:1337–1345, 2002.

Plata-Salaman CR, Peloso E, & Satinoff E. Cytokine-induced fever in obese (fa/fa) and lean (Fa/Fa) Zucker rats. Am. J. Physiol. 275 (Regulatory Integrative Comp. Physiol. 44):R1353-R1357, 1998.

Podolin DA, Wei Y, & Pagliassotti MJ. Effects of a high-fat diet and voluntary wheel running on gluconeogenesis and lipolysis in rats. J. Appl. Physiol. 86(4):1374-1380, 1999.

Razani B, Combs TP, Wang XB, Frank PG, Park DS, Russell RG, Li M, Tang B, Jelicks LA, Scherer PE, Lisanti MP. Caveolin-1 deficient mice are lean, resistant to diet-induced obesity, and show hyper-triglyceridemia with adipocyte abnormalities. J Biol. Chem., Mar 2002; 277: 8635 - 8647 ; 10.1074/jbc.M110970200

Scrocchi LA & Drucker DJ. Effects of Aging and a High Fat Diet on Body Weight and Glucose Tolerance in Glucagon-Like Peptide-1 Receptor -/- Mice. Endocrinology 139:3127-3132, 1998.

Shklyaev, S., et al. Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats. PNAS 100:24:14217–14222, 2003.

Sinha, Y., Thomas, J., Salocks, C., Wickes, M., Vanderlaan, W. (1977) Prolactin and growth hormone secretion in diet-induced obesity in mice. Horm Metab Res 9(4): 277-282.

Smagin GN, Howell LA, Redmann S, Ryan DH, & Harris RBS. Prevention of stress-induced weight loss by third ventricle CRF receptor antagonist. Am J Physiol. 276: R1461-R1468. 1999

Surwit RS, Dixon T, Petro A, Daniel K & Collins S. Diazoxide Restores Beta-three Adrenergic Receptor Function in Diet-Induced Obesity and Diabetes. Endocrinol. 2000: 141; 3630-3637

Surwit RS, et al. Differential effects of fat and sucrose on body composition in A/J and C57BL/6 mice. Metabolism.. 1998;47:1354-9.

Surwit RS, et al. Differential Effects of Fat and Sucrose on the Development of Obesity and Diabetes in C57BL/6J and A/J Mice. Metabolism. 1995; 44:645-651.

Surwit RS, et al. Pharmacologic manipulation of ob expression in a dietary model of obesity. J Biol Chem.. 1996; 271:9437-40.

Surwit RS, et al. Reversal of diet-induced obesity and diabetes in C57BL/6J mice. Metabolism.. 1998;47:1089-96.

Takahashi, N., et al. Divergent Effects of Leptin in Mice Susceptible or Resistant to Obesity. Horm Metab Res 34:691-697, 2002.

Tang H, Vasselli JR, Wu EX, Boozer CN, & Gallagher D. High-Resolution Magnetic Resonance Imaging Tracks Changes in Organ and Tissue Mass in Obese and Aging Rats. Am J Physiol (Regulatory Integrative Comp Physiol) 282:R890-R899, 2002.

Thupari, J. N., L. E. Landree, G. V. Ronnett, and F. P. Kuhajda. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. PNAS 99:14:9498–9502, 2002.

Tortoriello, D. V., J. Mcminn, and S. C. Chua. Dietary-Induced Obesity and Hypothalamic Infertility in Female DBA/2J Mice. Endocrinology 145: 1238–1247, 2004.

Triscari, J., Nauss-Karol, C., Levin, B. E., Sullivan, A. C. (1985) Changes in lipid metabolism in diet-induced obesity. Metab Clin Exp 34(6): 580-587.

Tulp, O. L., Stevens, C., Barbie, O. A. (1989) Non-shivering thermogenesis and obesity in adult diabetic Wistar fatty rats. Comp Biochem Physiol A Comp Physiol 92(1): 37-42.

Valet P, Grujic D, Wade J, Ito M, Zingaretti MC, Soloveva V, Ross SR, Graves RA, Cinti S, Lafontan M, and Lowell BB. Expression of human alpha 2-adrenergic receptors in adipose tissue of beta 3-adrenergic receptor-deficient mice promotes diet-induced obesity. J.Biol.Chem. 275: 34797-34802, 2000.

Van Heek M, Austin TM, et al. Rhesus monkeys develop variable obesity and metabolic profiles after chronic consumption of a high fat Western diet.

Van Heek M, et al. Diet-induced Obese Mice Develop Peripheral, but not Central Resistance to Leptin. J. Clin. Invest. 1997; 99:385-390.

Watson P, Commins S, Beiler R, Hatcher H & Gettys T. Differential regulation of leptin expression and function an A/J vs C57BL/6J mice during diet-induced obesity.Am J Physiol Endocrinol Metab. 2000: 279; E356-365.

Weigle, D. S. and B. E. Levin. Defective dietary induction of uncoupling protein 3 in skeletal muscle of obesity-prone rats. Obes.Res. 8: 385-391, 2000.

Weisberg, S. P., et al. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 112:1796–1808, 2003.

West DB, Delany JP, Camet, PM, Blohm F, Truett AA, & Scimeca J. Effects of conjugated lineolic acid on body fat and energy metabolism in the mouse. Am. J. Physiol. 1998; 276:R1172-R1179 (Regulatory Integrative Comp. Physiol. 45).

West, D. B., Boozer, C. N., Moody, D. L., Atkinson, R. L. (1992) Dietary obesity in nine inbred mouse strains. American J of Physiology 262(6), Part 2: R1025-1032.

Xu, H. et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 112:1821–1830, 2003.

Ziotopoulou M, Mantzoros CS, Hileman SM, & Flier JS. Differential expression of hypothalamic neuropeptides in the early phase of diet-induced obesity in mice. Am. J. Physiol. Endocrinol. Metab. 279:E383-E845, 2000.

Other References

Obesity